RapamycinFungusV1, Main, Exploration, bibRecord, 000214

TORC2 controls endocytosis through plasma membrane tension.

Identifieur interne : 000214 ( Main/Exploration ); précédent : 000213; suivant : 000215

TORC2 controls endocytosis through plasma membrane tension.

Auteurs : Margot Riggi [Suisse] ; Clélia Bourgoint [Suisse] ; Mariano Macchione [Suisse] ; Stefan Matile [Suisse] ; Robbie Loewith [Suisse] ; Aurélien Roux [Suisse]

Source :

The Journal of cell biology [ 1540-8140 ] ; 2019.

RBID : pubmed:31123183

Descripteurs français

KwdFr :
- Complexe-2 cible mécanistique de la rapamycine (génétique), Cytoplasme (génétique), Cytosquelette d'actine (génétique), Endocytose (génétique), Membrane cellulaire (génétique), Phosphorylation (MeSH), Protéines de Saccharomyces cerevisiae (génétique), Protéines des microfilaments (génétique), Protéines du cytosquelette (génétique), Protéines du transport vésiculaire (génétique), Saccharomyces cerevisiae (génétique), Transduction du signal (génétique).
MESH :
- génétique : Complexe-2 cible mécanistique de la rapamycine, Cytoplasme, Cytosquelette d'actine, Endocytose, Membrane cellulaire, Protéines de Saccharomyces cerevisiae, Protéines des microfilaments, Protéines du cytosquelette, Protéines du transport vésiculaire, Saccharomyces cerevisiae, Transduction du signal.
- Phosphorylation.

English descriptors

KwdEn :
- Actin Cytoskeleton (genetics), Cell Membrane (genetics), Cytoplasm (genetics), Cytoskeletal Proteins (genetics), Endocytosis (genetics), Mechanistic Target of Rapamycin Complex 2 (genetics), Microfilament Proteins (genetics), Phosphorylation (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (genetics), Signal Transduction (genetics), Vesicular Transport Proteins (genetics).
MESH :
- chemical , genetics : Cytoskeletal Proteins, Mechanistic Target of Rapamycin Complex 2, Microfilament Proteins, Saccharomyces cerevisiae Proteins, Vesicular Transport Proteins.
- genetics : Actin Cytoskeleton, Cell Membrane, Cytoplasm, Endocytosis, Saccharomyces cerevisiae, Signal Transduction.
- Phosphorylation.

Abstract

Target of rapamycin complex 2 (TORC2) is a conserved protein kinase that regulates multiple plasma membrane (PM)-related processes, including endocytosis. Direct, chemical inhibition of TORC2 arrests endocytosis but with kinetics that is relatively slow and therefore inconsistent with signaling being mediated solely through simple phosphorylation cascades. Here, we show that in addition to and independently from regulation of the phosphorylation of endocytic proteins, TORC2 also controls endocytosis by modulating PM tension. Elevated PM tension, upon TORC2 inhibition, impinges on endocytosis at two different levels by (1) severing the bonds between the PM adaptor proteins Sla2 and Ent1 and the actin cytoskeleton and (2) hindering recruitment of Rvs167, an N-BAR-containing protein important for vesicle fission to endocytosis sites. These results underline the importance of biophysical cues in the regulation of cellular and molecular processes.

DOI: 10.1083/jcb.201901096
PubMed: 31123183
PubMed Central: PMC6605812

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000268
to stream Main, to step Curation: 000268

Le document en format XML

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<term>Cytoskeletal Proteins (genetics)</term>
<term>Endocytosis (genetics)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (genetics)</term>
<term>Microfilament Proteins (genetics)</term>
<term>Phosphorylation (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
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<term>Cytoplasme (génétique)</term>
<term>Cytosquelette d'actine (génétique)</term>
<term>Endocytose (génétique)</term>
<term>Membrane cellulaire (génétique)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines des microfilaments (génétique)</term>
<term>Protéines du cytosquelette (génétique)</term>
<term>Protéines du transport vésiculaire (génétique)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
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<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Microfilament Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Vesicular Transport Proteins</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Actin Cytoskeleton</term>
<term>Cell Membrane</term>
<term>Cytoplasm</term>
<term>Endocytosis</term>
<term>Saccharomyces cerevisiae</term>
<term>Signal Transduction</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexe-2 cible mécanistique de la rapamycine</term>
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<term>Protéines des microfilaments</term>
<term>Protéines du cytosquelette</term>
<term>Protéines du transport vésiculaire</term>
<term>Saccharomyces cerevisiae</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Phosphorylation</term>
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<front><div type="abstract" xml:lang="en">Target of rapamycin complex 2 (TORC2) is a conserved protein kinase that regulates multiple plasma membrane (PM)-related processes, including endocytosis. Direct, chemical inhibition of TORC2 arrests endocytosis but with kinetics that is relatively slow and therefore inconsistent with signaling being mediated solely through simple phosphorylation cascades. Here, we show that in addition to and independently from regulation of the phosphorylation of endocytic proteins, TORC2 also controls endocytosis by modulating PM tension. Elevated PM tension, upon TORC2 inhibition, impinges on endocytosis at two different levels by (1) severing the bonds between the PM adaptor proteins Sla2 and Ent1 and the actin cytoskeleton and (2) hindering recruitment of Rvs167, an N-BAR-containing protein important for vesicle fission to endocytosis sites. These results underline the importance of biophysical cues in the regulation of cellular and molecular processes.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>14</Day>
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<DateRevised><Year>2020</Year>
<Month>05</Month>
<Day>14</Day>
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<Issue>7</Issue>
<PubDate><Year>2019</Year>
<Month>07</Month>
<Day>01</Day>
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<Title>The Journal of cell biology</Title>
<ISOAbbreviation>J Cell Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>TORC2 controls endocytosis through plasma membrane tension.</ArticleTitle>
<Pagination><MedlinePgn>2265-2276</MedlinePgn>
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<Abstract><AbstractText>Target of rapamycin complex 2 (TORC2) is a conserved protein kinase that regulates multiple plasma membrane (PM)-related processes, including endocytosis. Direct, chemical inhibition of TORC2 arrests endocytosis but with kinetics that is relatively slow and therefore inconsistent with signaling being mediated solely through simple phosphorylation cascades. Here, we show that in addition to and independently from regulation of the phosphorylation of endocytic proteins, TORC2 also controls endocytosis by modulating PM tension. Elevated PM tension, upon TORC2 inhibition, impinges on endocytosis at two different levels by (1) severing the bonds between the PM adaptor proteins Sla2 and Ent1 and the actin cytoskeleton and (2) hindering recruitment of Rvs167, an N-BAR-containing protein important for vesicle fission to endocytosis sites. These results underline the importance of biophysical cues in the regulation of cellular and molecular processes.</AbstractText>
<CopyrightInformation>© 2019 Riggi et al.</CopyrightInformation>
</Abstract>
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<Initials>M</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biochemistry, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>iGE3 Institute of Genetics and Genomics of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Swiss National Centre for Competence in Research Program Chemical Biology, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
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</AffiliationInfo>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
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<Initials>R</Initials>
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<AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, Geneva, Switzerland robbie.loewith@unige.ch.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>iGE3 Institute of Genetics and Genomics of Geneva, Geneva, Switzerland.</Affiliation>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

TORC2 controls endocytosis through plasma membrane tension.

TORC2 controls endocytosis through plasma membrane tension.

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